Chemca Chemistry Made Easy
Stereochemistry Visualization
Concept Quiz
Fischer Projections & Configuration
A Fischer projection is a 2D representation of a 3D chiral molecule. The viewing angle is strictly defined: horizontal lines represent bonds pointing towards the viewer (wedges), and vertical lines represent bonds pointing away from the viewer (dashes).
Swapping any 2 groups INVERTS the stereocenter ($R \rightleftharpoons S$).
Swapping pairs twice RETAINS the stereocenter ($R \rightarrow S \rightarrow R$).
Swapping pairs twice RETAINS the stereocenter ($R \rightarrow S \rightarrow R$).
R/S Rules in Fischer:
Draw a curve from Priority 1 $\rightarrow$ 2 $\rightarrow$ 3.
• If lowest priority (4) is on a Vertical bond: Keep the result (CW = R, CCW = S).
• If lowest priority (4) is on a Horizontal bond: Reverse it (CW = S, CCW = R).
Draw a curve from Priority 1 $\rightarrow$ 2 $\rightarrow$ 3.
• If lowest priority (4) is on a Vertical bond: Keep the result (CW = R, CCW = S).
• If lowest priority (4) is on a Horizontal bond: Reverse it (CW = S, CCW = R).
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Lecture Notes
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